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Angiography – The visualization of vessels

Angiography with flourescent dyes (e.g. ICG) can be a gentle alternative to other angiography methods in certain areas. However, the ICG absorption spectrum can change according to its concentration or depending on other blood components. This phenomenon is described »here.

HSI-camera technology can be a reliable tool to avoid this issue.

Our hyperspectral cameras are able to depict the absorption as well as the fluorescence of a dye in spectral resolution. Therefore, in chemometric analyses, spectral technologies have a clear advantage over the monochrome stimulation and imaging.

NIR Perfusion Index mit Sichtbarkeit der Gefäße

NIR-Perfusion mit Sichtbarkeit der Gefäße

NIR Perfusion Index with visibility of the vessels

NIR-Perfusion with visibility of the vessels

PAD – peripheral arterial disease
In PAD the arterial supply with oxygenated blood to the extremities is disturbed. This is almost always caused by arteriosclerosis. PAD is associated with an increased risk of cardiovascular disease, which can lead to heart attacks or strokes, among other things. Through the targeted use of our TIVITA® Tissue, early signs of the disease can be detected in a PAD.

“These results suggest the ability of hyperspectral imaging to detect the presence of PAD. Hyperspectral measurements can also evaluate different severities of PAD.
[J Vasc Surg 2011;54:1679-88.]

“Conclusion: We found sufficient evidence to use NIRS in clinical setting for assessment of chronic compartment syndrome of lower extremities, and as surveillance tool for detection of free flap failure. So far, clinical relevance of routine use of NIRS in other vascular applications is less clear. Cut-off values to discriminate are not yet unanimous and better validation has to be awaited for.”
[Boezeman, Reinout PE, et al. “Systematic review of clinical applications of monitoring muscle tissue oxygenation with near-infrared spectroscopy in vascular disease.” Microvascular research 104 (2016): 11-22.]

“Take Home Message: The study with 294 participants demonstrated the reliability of hyperspectral imaging to transcutaneous oximetry, ankle-brachial index, skin temperature, and severity of peripheral arterial disease with good correlation and low interoperator and intraoperator variability. Recommendation: The authors suggest that hyperspectral imaging may be useful as a screening tool in early-stage peripheral arterial disease.”
[Chiang, Nathaniel, et al. “Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease.” Journal of Vascular Surgery (2017).]

>>Chiang, Nathaniel, et al. “Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease.” Journal of Vascular Surgery (2017).

In good cooperation with the University Hospital Greifswald, the success of two therapeutic approaches on one foot of a pAD patient with the TIVITA® was shown.
Firstly, the cold plasma therapy was applied, the pictures were taken, immediately after and ten minutes after the treatment. The treatment causes an increase in the oxygen content in the wound and the entire foot.

Nachweis der Erhöhung der Sauerstoffversorgung am Fuß eines pAVK-Patienten mit der Kaltplasmatherapie

Increase of oxygen supply to the foot of a PAD patient with cold plasma therapy

On the other hand, the following results could be worked out with the topical oxygen therapy.
>>Nachweis der Erhöhung der Sauerstoffversorgung am Fuß eines pAVK-Patienten mit der topischen Sauerstofftherapie (Advanced Oxygen Therapy Inc.)

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