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Diaspective Vision



  1. Fodor M, Zelger P, Pallua JD, Huck CW, Hofmann J, Otarashvili G, Pühringer M, Zelger B, Hermann M, Resch T, Cardini B, Oberhuber R, Öfner D, Sucher R, Hautz T, Schneeberger S. Prediction of Biliary Complications After Human Liver Transplantation Using Hyperspectral Imaging and Convolutional Neural Networks: A Proof-of-concept Study. Transplantation. 2024 Feb 1;108(2):506-515. doi: 10.1097/TP.0000000000004757
  2. Ilgen A, Köhler H, Pfahl A, Stelzner S, Mehdorn M, Jansen-Winkeln B, Gockel I, Moulla Y.  Intraoperative Laparoscopic Hyperspectral Imaging during Esophagectomy-A Pilot Study Evaluating Esophagogastric Perfusion at the Anastomotic Sites. Bioengineering (Basel). 2024 Jan 9;11(1):69. doi: 10.3390/bioengineering11010069
  3. Pertzborn D, Bali A, Mühlig A, von Eggeling F, Guntinas-Lichius O. Hyperspectral imaging and evaluation of surgical margins: where do we stand? Curr Opin Otolaryngol Head Neck Surg. 2024 Jan 4. doi: 10.1097/MOO.0000000000000957


  1. Pfahl A, Polat ST, Köhler H, Gockel I, Melzer A, Chalopin C. Switchable LED-based laparoscopic multispectral system for rapid high-resolution perfusion imaging. J Biomed Opt. 2023;28(12):126002. doi: 10.1117/1.JBO.28.12.126002
  2. Kuhlmann H, Garczarek L, Künne D, Pattberg K, Skarabis A, Frank M, Schmidt B, Arends S, Herbstreit F, Brenner T, Schmidt K, Espeter F. Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study. Bioengineering. 2023; 10(10):1167. doi: 10.3390/bioengineering10101167
  3. Studier-Fischer A, Schwab FM, Rees M, Seidlitz S, Sellner J, Özdemir B, Ayala L, Odenthal J, Knoedler S, Kowalewski KF, Haney CM, Dietrich M, Salg GA, Kenngott HG; Müller-Stich BP, Maier-Hein L, Nickel F. ICG-augmented hyperspectral imaging for visualization of intestinal perfusion compared to conventional ICG fluorescence imaging – An experimental study. International Journal of Surgery. Sept 15, 2023. doi: 10.1097/JS9.0000000000000706
  4. Wagner T, Mustafov O, Hummels M, Grabenkamp A, Thomas MN, Schiffmann LM, Bruns CJ, Stippel DL, Wahba R. Imaged guided surgery during arteriovenous malformation of gastrointestinal stromal tumor using hyperspectral and indocyanine green visualization techniques: A case report. World J Clin Cases. 2023;11(23):5530-5537. doi: 10.12998/wjcc.v11.i23.5530
  5. Schulz T, Nuwayhida R, Houschyar KS, Langer S, Kohler L. Diagnostical accuracy of hyperspectral imaging after free flap surgery.  J Plast Surg Hand Surg. 2023;58:48-55. doi: 10.2340/jphs.v58.7140
  6. Traber J, Wild T, Marotz J, Berli MC, Franco-Obregón A. Concurrent Optical- and Magnetic-Stimulation-Induced Changes on Wound Healing Parameters, Analyzed by Hyperspectral Imaging: An Exploratory Case Series. Bioengineering (Basel). 2023 Jun 23;10(7):750. doi: 10.3390/bioengineering10070750
  7. Son GM, Nazir AM, Yun MS, Lee IY, Im SB, Kwak JY, Park SH, Baek KR, Gockel I. The Safe Values of Quantitative Perfusion Parameters of ICG Angiography Based on Tissue Oxygenation of Hyperspectral Imaging for Laparoscopic Colorectal Surgery: A Prospective Observational Study. Biomedicines. 2023;11(7):2029. doi: 10.3390/biomedicines11072029
  8. Vaz Pimentel D, Merten L, Gosemann JH, Gockel I, Jansen-Winkeln B, Mayer S, Lacher M. Hyperspectral Imaging-A Novel Tool to Assess Tissue Perfusion and Oxygenation in Esophageal Anastomoses. European J Pediatr Surg Rep. 2023;11(1):e32-e35. doi: 10.1055/s-0043-1769106
  9. Studier-Fischer A, Seidlitz S, Sellner J, Bressan M, Özdemir B, Ayala L, Odenthal J, Knoedler S, Kowalewski KF, Haney CM, Salg G, Dietrich M, Kenngott H, Gockel I, Hackert T, Müller-Stich BP, Maier-Hein L, Nickel F. HeiPorSPECTRAL – the Heidelberg Porcine HyperSPECTRALImaging Dataset of 20 Physiological Organs. Sci Data. 2023;10(1):414. doi: 10.1038/s41597-023-02315-8
  10. Tkachenko M, Chalopin C, Jansen-Winkeln B, Neumuth T, Gockel I, Maktabi M. Impact of Pre- and Post-Processing Steps for Supervised Classification of Colorectal Cancer in Hyperspectral Images. Cancers (Basel). 2023 Apr 5;15(7):2157. doi: 10.3390/cancers15072157
  11. Nickel F, Studier-Fischer A, Özdemir B, Odenthal J, Müller LR, Knoedler S, Kowalewski KF, Camplisson I, Allers MM, Dietrich M, Schmidt K, Salg GA, Kenngott HG, Billeter AT, Gockel I, Sagiv C, Hadar OE, Gildenblat J, Ayala L, Seidlitz S, Maier-Hein L, Müller-Stich BP. Optimization of anastomotic technique and gastric conduit perfusion with hyperspectral imaging and machine learning in an experimental model for minimally invasive esophagectomy. European Journal of Surgical Oncology. 2023. doi: 10.1016/j.ejso.2023.04.007
  12. Ellebrecht D. Hyperspectral imaging enables the differentiation of differentially inflated and perfused pulmonary tissue: a proof-of-concept study in pulmonary lobectomies for intersegmental plane mapping. Biomedical Engineering / Biomedizinische Technik. 2023. doi: 10.1515/bmt-2022-0389
  13. Dietrich M, Antonovici A, Hölle T, Nusshag C, Kapp AC, Studier-Fischer A, Arif R, Nickel F, Weigand MA, Frey N, Lichtenstern C, Leuschner F, Fischer D. Microcirculatory tissue oxygenation correlates with kidney function after transcatheter aortic valve implantation-Results from a prospective observational study. Front Cardiovasc Med. 2023;10:1108256. doi: 10.3389/fcvm.2023.1108256
  14. Zimmermann A, Köhler H, Chalopin C, Jansen-Winkeln B, Nowotny R, Schönherr T, Mehdorn M, Uttinger KL, Thieme R, Gockel I, Moulla Y. The role of intraoperative hyperspectral imaging (HSI) in colon interposition after esophagectomy. BMC Surg. 2023;23(1):47. doi: 10.1186/s12893-023-01946-3
  15. Ellebrecht DB, Kugler C. Intraoperative Determination of Bronchus Stump and Anastomosis Perfusion with Hyperspectral Imaging. Surg Innov. 2023 Feb 21:15533506231157165. doi: 10.1177/15533506231157165. Online ahead of print.
  16. Pathak P, Chalopin C, Zick L, Köhler H, Pfahl A, Rayes N, Gockel I, Neumuth T, Melzer A, Jansen-Winkeln B, Maktabi M. Spectral Similarity Measures for In Vivo Human Tissue Discrimination Based on Hyperspectral Imaging. Diagnostics (Basel). 2023;13(2):195. doi: 10.3390/diagnostics13020195
  17. Thomaßen MT, Köhler H, Pfahl A, Stelzner S, Mehdorn M, Thieme R, Jansen-Winkeln B, Gockel I, Chalopin C, Moulla Y. In vivo evaluation of a hyperspectral imaging system for minimally invasive surgery (HSI-MIS). Surg Endosc. 2023 May;37(5):3691-3700. doi: 10.1007/s00464-023-09874-2.
  18. Thoenissen P, Heselich A, Al-Maawi S, Sader R, Ghanaati S. Hyperspectral Imaging Allows Evaluation of Free Flaps in Craniomaxillofacial Reconstruction. J Craniofac Surg. 2023 May 1;34(3):e212-e216. doi: 10.1097/SCS.0000000000009009


  1. Son GM, Kim TU, Shin DH, Na JY, Lee IY, Park SH.  Ileal long-segment ischemia after the unintended ligation of variant ileal branch during laparoscopic right hemicolectomy. J Minim Invasive Surg. 2022;25(3):116-119. doi: 10.7602/jmis.2022.25.3.116
  2. Pertzborn D, Nguyen HN, Hüttmann K, Prengel J, Ernst G, Guntinas-Lichius O, von Eggeling F, Hoffmann F. Intraoperative Assessment of Tumor Margins in Tissue Sections with Hyperspectral Imaging and Machine Learning. Cancers (Basel). 2022;15(1):213. doi: 10.3390/cancers15010213
  3. Hren R, Sersa G, Simoncic U, Milanic M. Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review. Radiol Oncol. 2022;56(4):420-429. doi: 10.2478/raon-2022-0051
  4. Katzenschlager S, Dietrich M, Peterstorfer F, Manten K, von der Forst M, Behnisch R, Leowardi C, Studier-Fischer A, Nickel F, Weigand MA, Weilbacher F, Popp E. Implementation of hyperspectral imaging in a trauma resuscitation room: a randomized controlled trial. Scand J Trauma Resusc Emerg Med. 2022;30(1):66. doi: 10.1186/s13049-022-01057-7
  5. Martinez-Vega B, Tkachenko M, Matkabi M, Ortega S, Fabelo H, Balea-Fernandez F, La Salvia M, Torti E, Leporati F, Callico GM, Chalopin C. Evaluation of Preprocessing Methods on Independent Medical Hyperspectral Databases to Improve Analysis. Sensors. 2022; 22(22):8917. doi: 10.3390/s22228917
  6. Borchardt T, Helmke A, Ernst J, Emmert S, Schilling AF, Felmerer G, Viöl W. Topically confined enhancement of cutaneous microcirculation by cold plasma. Skin Pharmacol Physiol. 2022. doi: 10.1159/000527700
  7. Kneifel F, Wagner T, Flammang I, Vogt F, Katou S, Vogel T, Houben P, Becker F, Wahl P, Pascher A, Radunz S. Hyperspectral Imaging for Viability Assessment of Human Liver Allografts During Normothermic Machine Perfusion. Transplant Direct. 2022;8(12):e1420. doi: 10.1097/TXD.0000000000001420
  8. Felli E, Cinelli L, Bannone E, Giannone F, Muttillo EM, Barberio M, Keller DS, Rodríguez-Luna MR, Okamoto N, Collins T, Hostettler A, Schuster C, Mutter D, Pessaux P, Marescaux J, Gioux S, Felli E, Diana M. Hyperspectral Imaging in Major Hepatectomies: Preliminary Results from the Ex-Machyna Trial. Cancers. 2022;14(22):5591. doi: 10.3390/cancers14225591
  9. Köhler H, Pfahl A, Moulla Y, Thomaßen MT, Maktabi M, Gockel I, Neumuth T, Melzer A, Chalopin C. Comparison of image registration methods for combining laparoscopic video and spectral image data. Sci Rep. 2022;12(1):16459. doi: 10.1038/s41598-022-20816-1
  10. Automatic optical biopsy for colorectal cancer using hyperspectral imaging and artificial neural networks. Surg Endosc. 2022;36(11):8549-8559. doi: 10.1007/s00464-022-09524-z
  11. Okamoto N, Rodríguez-Luna MR, Bencteux V, Al-Taher M, Cinelli L, Felli E, Urade T, Nkusi R, Mutter D, Marescaux J, Hostettler A, Collins T, Diana M. Computer-Assisted Differentiation between Colon-Mesocolon and Retroperitoneum Using Hyperspectral Imaging (HSI) Technology. Diagnostics (Basel). 2022;12(9):2225. doi: 10.3390/diagnostics12092225
  12. Wagner T, Katou S, Wahl P, Vogt F, Kneifel F, Morgul H, Vogel T, Houben P, Becker F, Struecker B, Pascher A, Radunz S. Hyperspectral imaging for quantitative assessment of hepatic steatosis in human liver allografts. Clin Transplant. 2022:e14736. doi: 10.1111/ctr.14736
  13. Wagner T, Radunz S, Becker F, Chalopin C, Kohler H, Gockel I, Jansen-Winkeln Boris. Hyperspectral imaging detects perfusion and oxygenation differences between stapled and hand-sewn intestinal anastomoses. Innovative Surgical Sciences. 2022. doi: 10.1515/iss-2022-0007
  14. Thiem DGE, Siegberg F, Römer P, Blatt S, Pabst A, Heimes D, Al-Nawas B, Kämmerer PW. Long-Term Donor Site Morbidity and Flap Perfusion Following Radial versus Ulnar Forearm Free Flap-A Randomized Controlled Prospective Clinical Trial. J Clin Med. 2022;11(13):3601. doi: 10.3390/jcm11133601
  15. Chalopin C, Nickel F, Pfahl A, Köhler H, Maktabi M, Thieme R, Sucher R, Jansen-Winkeln B, Studier-Fischer A, Seidlitz S, Maier-Hein L, Neumuth T, Melzer A, Müller-Stich BP, Gockel I. [Artificial intelligence and hyperspectral imaging for image-guided assistance in minimally invasive surgery]. Chirurgie (Heidelb). 2022;93(10):940-947. doi: 10.1007/s00104-022-01677-w
  16. Barberio M, Lapergola A, Benedicenti S, Mita M, Barbieri V, Rubichi F, Altamura A, Giaracuni G, Tamburini E, Diana M, Pizzicannella M, Viola MG. Intraoperative bowel perfusion quantification with hyperspectral imaging: a guidance tool for precision colorectal surgery. Surg Endosc. 2022;36(11):8520-8532. doi: 10.1007/s00464-022-09407-3
  17. Becker P, Blatt S, Pabst A, Heimes D, Al-Nawas B, Kämmerer PW, Thiem DGE. Comparison of Hyperspectral Imaging and Microvascular Doppler for Perfusion Monitoring of Free Flaps in an In Vivo Rodent Model. J Clin Med. 2022;11(14):4134. doi: 10.3390/jcm11144134
  18. Fodor M, Lanser L, Hofmann J, Otarashvili G, Pühringer M, Cardini B, Oberhuber R, Resch T, Weissenbacher A, Maglione M, Margreiter C, Zelger P, Pallua JD, Öfner D, Sucher R, Hautz T, Schneeberger S. Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study. Transpl Int. 2022;35:10355. doi: 10.3389/ti.2022.10355
  19. Sucher E, Sucher R, Guice H, Schneeberger S, Brandacher G, Gockel I, Berg T, Seehofer D. Hyperspectral Evaluation of the Human Liver During Major Resection. Annals of Surgery. 2022;2:e169. doi: 10.1097/AS9.0000000000000169
  20. Pfahl A, Radmacher GK, Köhler H, Maktabi M, Neumuth T, Melzer A, Gockel I, Chalopin C, Jansen-Winkeln B. Combined indocyanine green and quantitative perfusion assessment with hyperspectral imaging during colorectal resections. Biomed Opt Express. 2022;13(5):3145-3160. doi: 10.1364/BOE.452076 2022 May 1.
  21. Studier-Fischer A, Seidlitz S, Sellner J, Özdemir B, Wiesenfarth M, Ayala L, Odenthal J, Knödler S, Kowalewski KF, Haney CM, Camplisson I, Dietrich M, Schmidt K, Salg GA, Kenngott HG, Adler TJ, Schreck N, Kopp-Schneider A, Maier-Hein K, Maier-Hein L, Müller-Stich BP, Nickel F. Spectral organ fingerprints for machine learning-based intraoperative tissue classification with hyperspectral imaging in a porcine model. Sci Rep. 2022;12(1):11028. doi: 10.1038/s41598-022-15040-w
  22. Seidlitz S, Sellner J, Odenthal J, Özdemir B, Studier-Fischer A, Knödler S, Ayala L, Adler TJ, Kenngott HG, Tizabi M, Wagner M, Nickel F, Müller-Stich BP, Maier-Hein L. Robust deep learning-based semantic organ segmentation in hyperspectral images. Med Image Anal. 2022;80:102488. doi: 10.1016/
  23. Wuarin L, Mugnai D, Diaper J, Huber C, Murith N. Hyperspectral imaging for the assessment and monitoring of lower limb perfusion in vascular patients. Open J Clin Med Images. 2022; 2(1): 1036.
  24. Romann S, Wagner T, Katou S, Reuter S, Vogel T, Becker F, Morgul H, Houben P, Wahl P, Pascher A, Radunz S. Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation. Diagnostics. 2022;12:1194. doi: 10.3390/diagnostics12051194
  25. Pfahl A, Köhler H, Thomaßen MT, Maktabi M, Bloße AM, Mehdorn M, Lyros O, Moulla Y, Niebisch S, Jansen-Winkeln B, Chalopin C, Gockel I. Video: Clinical evaluation of a laparoscopic hyperspectral imaging system. Surg Endosc. 2022;36(10):7794-7799. doi: 10.1007/s00464-022-09282-y
  26. Mehdorn M, Gockel I, Jansen-Winkeln B, Meyer HJ. Akute Mesenterialischämie. Standard und Innovationen der serologischen und bildgebenden Diagnostik. Coloproctology. 2022;44(2):97-103. doi: 10.1007/s00053-022-00594-0
  27. Grambow E, Sandkühler NA, Groß J, Thiem DGE, Dau M, Leuchter M, Weinrich M. Evaluation of Hyperspectral Imaging for Follow-Up Assessment after Revascularization in Peripheral Artery Disease. J Clin Med. 2022;11(3):758. doi: 10.3390/jcm11030758
  28. Maktabi M, Wichmann Y, Köhler H, Ahle H, Lorenz D, Bange M, Braun S, Gockel I, Chalopin C, Thieme R. Tumor cell identification and classification in esophageal adenocarcinoma specimens by hyperspectral imaging. Sci Rep. 2022;12(1):4508. doi: 10.1038/s41598-022-07524-6
  29. Jansen-Winkeln B, Dvorak M, Köhler H, Maktabi M, Mehdorn M, Chalopin C, Diana M, Gockel I, Barberio M. Border Line Definition Using Hyperspectral Imaging in Colorectal Resections. Cancers. 2022;14(5):1188. doi: 10.3390/cancers14051188
  30. Knospe L, Gockel I, Jansen-Winkeln B, Thieme R, Niebisch S, Moulla Y, Stelzner S, Lyros O, Diana M, Marescaux J, Chalopin C, Köhler H, Pfahl A, Maktabi M, Park JH, Yang HK. New Intraoperative Imaging Tools and Image-Guided Surgery in Gastric Cancer Surgery. Diagnostics. 2022;12(2):507. doi: 10.3390/diagnostics12020507
  31. Sommer F, Sun B, Fischer J, Goldammer M, Thiele C, Malberg H, Markgraf W. Hyperspectral Imaging during Normothermic Machine Perfusion—A Functional Classification of Ex Vivo Kidneys Based on Convolutional Neural Networks. Biomedicines. 2022;10(2):397. doi: 10.3390/biomedicines10020397
  32. Wolters K, Garabet W, Makosch M, Simon F, Schelzig H, Rembe JD. Hyperspektrale Bildgebung in der Wund- und Gefäßmedizin als neue diagnostische Dimension: Technische Grundlagen und medizinische Anwendung – Teil 2. Gefässchirurgie. 2022;27:46–50. doi: 10.1007/s00772-021-00857-y
  33. Kistler M, Köhler H, Theopold J, Gockel I, Roth A, Hepp P, Osterhoff G. Intraoperative hyperspectral imaging (HSI) as a new diagnostic tool for the detection of cartilage degeneration. Sci Rep. 2022;12(1):608. doi: 10.1038/s41598-021-04642-5
  34. Pruimboom T, Lindelauf AAMA, Felli E, Sawor JH, Deliaert AEK, van der Hulst RRWJ, Al-Taher M, Diana M, Schols RM. Perioperative Hyperspectral Imaging to Assess Mastectomy Skin Flap and DIEP Flap Perfusion in Immediate Autologous Breast Reconstruction: A Pilot Study. Diagnostics. 2022;12:184. doi: 10.3390/diagnostics12010184
  35. Lindelauf AAMA, Saelmans AG, van Kuijk SMJ, van der Hulst RRWJ, Schols RM. Near-Infrared Spectroscopy (NIRS) versus Hyperspectral Imaging (HSI) to Detect Flap Failure in Reconstructive Surgery: A Systematic Review. Life. 2022;12:65. doi: 10.3390/life12010065
  36. Hennig S, Jansen-Winkeln B, Köhler H, Knospe L, Chalopin C, Maktabi M, Pfahl A, Hoffmann J, Kwast S, Gockel I, Moulla Y. Novel Intraoperative Imaging of Gastric Tube Perfusion during Oncologic Esophagectomy—A Pilot Study Comparing Hyperspectral Imaging (HSI) and Fluorescence Imaging (FI) with Indocyanine Green (ICG). Cancers. 2022;14(1):97. doi: 10.3390/cancers14010097
  37. Schulz T, Marotz J, Seider S, Langer S, Leuschner S, Siemers F. Burn depth assessment using hyperspectral imaging in a prospective single center study. Burns. 2022;48(5):1112-1119. doi: 10.1016/j.burns.2021.09.010
  38. Sucher R, Wagner T, Köhler H, Sucher E, Guice H, Recknagel S, Lederer A, Hau H M, Rademacher S, Schneeberger S, Brandacher G, Gockel I, Seehofer D. Hyperspectral Imaging (HSI) of Human Kidney Allografts. Ann Surg. 2022;276(1):e48-e55. doi: 10.1097/SLA.0000000000004429
  39. Promny D, Aich J, Püski T, Marti Edo A, Reichert B, Billner M. Evaluation of hyperspectral imaging as a modern aid in clinical assessment of burn wounds of the upper extremity. Burns. 2022;48(3):615-622. doi: 10.1016/j.burns.2021.06.013
  40. Sucher R, Scheuermann U, Rademacher S, Lederer A, Sucher E, Hau HM, Brandacher G, Schneeberger S, Gockel I, Seehofer D. Intraoperative reperfusion assessment of human pancreas allografts using hyperspectral imaging (HSI). Hepatobiliary Surg Nutr. 2022;11(1):67-77. doi: 10.21037/hbsn-20-744
  41. Eggert D, Bengs M, Westermann S, Gessert N, Gerstner AOH, Mueller NA, Bewarder J, Schlaefer A, Betz C, Laffers W. In vivo detection of head and neck tumors by hyperspectral imaging combined with deep learning methods. J Biophotonics. 2022;15(3):e202100167. doi: 10.1002/jbio.202100167
  42. Linek M, Felicio-Briegel A, Freymüller C, Rühm A, Englhard AS, Sroka R, Volgger V. Evaluation of hyperspectral imaging to quantify perfusion changes during the modified Allen test. Lasers Surg Med. 2022;54(10):1321. doi: 10.1002/lsm.23587


  1. Wolters K, Garabet W, Makosch M, Simon F, Schelzig H, Rembe JD. Hyperspektrale Bildgebung in der Wund- und Gefäßmedizin als neue diagnostische Dimension: Technische Grundlagen und medizinische Anwendung – Teil 1. Gefässchirurgie. 2021;26:624–628. doi: 10.1007/s00772-021-00837-2
  2. Dietrich M, Özdemir B, Gruneberg D, Petersen C, Studier-Fischer A, von der Forst M, Schmitt FCF, Fiedler MO, Nickel F, Müller-Stich BP, Brenner T, Weigand MA, Uhle F, Schmidt K. Hyperspectral Imaging for the Evaluation of Microcirculatory Tissue Oxygenation and Perfusion Quality in Haemorrhagic Shock: A Porcine Study. Biomedicines. 2021;9:1829. doi: 10.3390/biomedicines9121829
  3. Dietrich M, Marx S, von der Forst M, Bruckner T, Schmitt FCF, Fiedler MO, Nickel F, Studier-Fischer A, Müller-Stich BP, Hackert T, Brenner T, Weigand MA, Uhle F, Schmidt K. Hyperspectral imaging for perioperative monitoring of microcirculatory tissue oxygenation and tissue water content in pancreatic surgery – an observational clinical pilot study. Perioper Med (Lond). 2021;10(1):42. doi: 10.1186/s13741-021-00211-6
  4. Nischwitz SP, Luze H, Schellnegger M, Gatterer SJ, Tuca AC, Winter R, Kamolz LP. Thermal, Hyperspectral, and Laser Doppler Imaging: Non-Invasive Tools for Detection of The Deep Inferior Epigastric Artery Perforators-A Prospective Comparison Study. J Pers Med. 2021;11(10):1005. doi: 10.3390/jpm11101005
  5. Maktabi M, Tkachenko M, Kohler H, Schierle K, Gockel I, Jansen-Winkeln B, Chalopin C. Using physiological parameters measured by hyperspectral imaging to detect colorectal cancer. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3865-3868. doi: 10.1109/EMBC46164.2021.9630160
  6. De Landro M, Felli E, Collins T, Nkusi R, Baiocchini A, Barberio M, Orrico A, Pizzicannella M, Hostettler A, Diana M, Saccomandi P. Prediction of In Vivo Laser-Induced Thermal Damage with Hyperspectral Imaging Using Deep Learning. Sensors. 2021; 21(20):6934. doi: 10.3390/s21206934
  7. Barberio M, Benedicenti S, Pizzicannella M, Felli E, Collins T, Jansen-Winkeln B, Marescaux J, Viola MG, Diana M. Intraoperative Guidance Using Hyperspectral Imaging: A Review for Surgeons. Diagnostics. 2021; 11(11):2066. doi: 10.3390/diagnostics11112066
  8. Thiem DGE, Römer P, Blatt S, Al-Nawas B, Kämmerer PW. New Approach to the Old Challenge of Free Flap Monitoring-Hyperspectral Imaging Outperforms Clinical Assessment by Earlier Detection of Perfusion Failure. J Pers Med. 2021, 11, 1101. doi: 10.3390/jpm11111101
  9. Nickel F, Studier-Fischer A, Özdemir B, Odenthal J, Müller LR, Knödler S, Kowalewski KF, Camplisson I, Allers MM, Dietrich M, Schmidt K, Salg GA, Kenngott HG, Billeter AT, Gockel I, Sagiv C, Hadar OE, Gildenblat J, Ayala L, Seidlitz S, Maier-Hein L, Müller-Stich BP. Optimization of anastomotic technique and gastric conduit perfusion with hyperspectral imaging in an experimental model for minimally invasive esophagectomy. bioRxiv. 2021. doi: 10.1101/2021.10.03.462901
  10. Chalopin C, Maktabi M, Köhler H, Cervantes-Sanchez F, Pfahl A, Jansen-Winkeln B, Mehdorn M, Barberio M, Gockel I, Melzer A. (2021) Intraoperative Imaging for Procedures of the Gastrointestinal Tract. In: Horgan S., Fuchs KH. (eds) Innovative Endoscopic and Surgical Technology in the GI Tract. Springer, Cham. doi: 10.1007/978-3-030-78217-7_32
  11. Collins T, Maktabi M, Barberio M, Bencteux V, Jansen-Winkeln B, Chalopin C, Marescaux J, Hostettler A, Diana M, Gockel I. Automatic Recognition of Colon and Esophagogastric Cancer with Machine Learning and Hyperspectral Imaging. Diagnostics. 2021; 11(10):1810. doi: 10.3390/diagnostics11101810
  12. Barberio M, Collins T, Bencteux V, Nkusi R, Felli E, Viola MG, Marescaux J, Hostettler A, Diana M. Deep Learning Analysis of In Vivo Hyperspectral Images for Automated Intraoperative Nerve Detection. Diagnostics (Basel). 2021 Aug 21;11(8):1508. doi: 10.3390/diagnostics11081508
  13. van Welzen A, Hoch M, Wahl P, Weber F, Rode S, Tietze JK, Boeckmann L, Emmert S, Thiem A. The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study. Skin Pharmacol Physiol. 2021; Aug 6:1-9. doi: 10.1159/000517524
  14. Thiem DGE, Römer P, Gielisch M, Al-Nawas B, Schlüter M, Plaß B, Kämmerer PW. Hyperspectral imaging and artificial intelligence to detect oral malignancy – part 1 – automated tissue classification of oral muscle , fat and mucosa using a light- weight 6-layer deep neural network. Head & Face Medicine. 2021;17:38. doi: 10.1186/s13005-021-00292-0
  15. Cervantes-Sanchez F, Maktabi M, Köhler H, Sucher R, Rayes N, Avina-Cervantes JG, Cruz-Aceves I, Chalopin C. Automatic tissue segmentation of hyperspectral images in liver and head neck surgeries using machine learning. Art Int Surg. 2021; 1:22-37. doi: 10.20517/ais.2021.05
  16. Fodor M, Hofmann J, Lanser L, Otarashvili G, Pühringer M, Hautz T, Sucher R, Schneeberger S. Hyperspectral Imaging and Machine Perfusion in Solid Organ Transplantation: Clinical Potentials of Combining Two Novel Technologies. J Clin Med. 2021; 10(17): 3838. doi: 10.3390/jcm10173838
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  18. Thiem DGE, Hans L, Blatt S, Römer P, Heimes D, Al-Nawas B, Kämmerer PW. Hyperspectral Imaging to Study Dynamic Skin Perfusion after Injection of Articaine-4% with and without Epinephrine—Clinical Implications on Local Vasoconstriction. J Clin Med. 2021; 10(15):3411. doi: 10.3390/jcm10153411
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  22. Jansen-Winkeln B, Mehdorn M, Lange UG, Köhler H, Chalopin C, Gockel I. Precision Surgery In Rectal Resection With Hyperspectral And Fluorescence Imaging And Pelvic Intraoperative Neuromonitoring (With Video). Surg Technol Int. 2021 May 20;38:154-158. doi: 10.52198/21.STI.38.CR1383
  23. Heimes D, Becker P, Thiem DGE, Kuchen R, Kyyak S, Kämmerer PW. Is Hyperspectral Imaging Suitable for Assessing Collateral Circulation Prior Radial Forearm Free Flap Harvesting? Comparison of Hyperspectral Imaging and Conventional Allen’s Test. J Pers Med. 2021;11(6):531. doi: 10.3390/jpm11060531
  24. Kohler LH, Köhler H, Kohler S, Langer S, Nuwayhid R, Gockel I, Spindler N, Osterhoff G. Hyperspectral Imaging (HSI) as a new diagnostic tool in free flap monitoring for soft tissue reconstruction: a proof of concept study. BMC Surg. 2021 Apr 30;21(1):222. doi: 10.1186/s12893-021-01232-0
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  30. Berlth F, Knospe L, Jansen-Winkeln B, Hadzijusufovic E, Tagkalos E, Niebisch S, Moulla Y, Chalopin C, Köhler H, Maktabi M, Lang H, Grimminger P, Gockel I. [Status of minimally invasive gastrectomy : Current advancements: robotic surgery and intraoperative imaging for gastric cancer]. Chirurg. 2021 Jun;92(6):528-534. doi: 10.1007/s00104-021-01391-z
  31. Jansen-Winkeln B, Barberio M, Chalopin C, Schierle K, Diana M, Köhler H, Gockel I, Maktabi M. Feedforward Artificial Neural Network-Based Colorectal Cancer Detection Using Hyperspectral Imaging: A Step towards Automatic Optical Biopsy. Cancers (Basel). 2021;13(5):967. doi: 10.3390/cancers13050967
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  33. Promny D, Aich J, Billner M, Reichert B. First preliminary Clinical Experiences using Hyperspectral Imaging for Burn Depth Assessment of Hand Burns. J Burn Care Res. 2021 May 20:irab082. doi: 10.1093/jbcr/irab082
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  35. De Landro M, Espíritu García-Molina I, Barberio M, Felli E, Agnus V, Pizzicannella M, Diana M, Zappa E, Saccomandi P. Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver. Sensors (Basel). 2021;21(2):643. doi: 10.3390/s21020643
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  40. Barberio M, Felli E, Pizzicannella M, Agnus V, Al-Taher M, Seyller E, Moulla Y, Jansen-Winkeln B, Gockel I, Marescaux J, Diana M. Quantitative serosal and mucosal optical imaging perfusion assessment in gastric conduits for esophageal surgery: an experimental study in enhanced reality. Surg Endosc. 2021 Oct;35(10):5827-5835. doi: 10.1007/s00464-020-08077-3
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